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Viagra, is a brand name well-known for the drug Sildenafil citrate. It is also sold under the name Ravatio and Cavertia in few places across the world. It is developed, produced and marketed by the pharmaceutical company Pfizer. The prime competitors of Pfizer in the market are tadalafil (Cialis) and Vardenafil (Levitra). The main purpose for the production of this drug is to treat male erectile dysfunction (ED or impotence) and pulmonary arterial hypertension (PAH). Viagra is obtained in three different dosages; 25mg, 50mg, and 100mg. This drug is comes through doctor’s prescription. But these days it is gained on internet also as it is widespread.

Initially Viagra was not intended to treat ED. In the late 1990s it was formed to cure a form of heart disease called angina pectoris. As it did not work that purpose and showed few signs of consistent erections. It was then that the drug was patented in 1996 and approved for the treatment of ED. ED is a common complaint in men, which occurs due to several factors. Many of the causes can be due to psychological reasons whereas few causes can be due to physiological disorders. It is found that every 1 in 10 men suffer with ED at some point in their lives. In few cases of ED, which is caused by the damage to the nervous system, diabetes or hypogonadism, and these cases Viagra may not be effective.

Viagra is ranked as a phosphodiesterase type5 (PDE5) inhibitor. Basically PDE5 results in a compound called cyclic guanosine monophosphate or cGMP to lower. As the cGMP causes the arterial smooth muscles in the penis to relax, which then allows the penis becomes congest with blood which is how an erection is generated. A few other drugs which perform on the same procedures are Tadalafil and Vardenafil. Sildenafil is metabolized by hepatic enzymes and excreted by both the liver and kidneys.

As mentioned earlier, Viagra is found to be sold in three different dosages of 25mg, 50mg and 100mg. All three costing US$10 per pill. Usually it is recommended to start the medication with 50mg pill and then the dosage is lowered or raised accordingly which is appropriate. And the dosage for the pulmonary arterial hypertension which is cured by the drug Revatio is a 20mg pill three times a day. The Viagra pills are blue and diamond shaped pills with the words ‘Pfizer’ engraved on one side and ‘VGR xx’ engraved on the other side of it. Xx stands for the dosage of the pill such as 25 or 50 or 100. Viagra certainly has few side effects. Few of the common side effects are sneezing, headache, stomach upset, flushing and sweating. The list also includes dyspepsia (indigestion), palpitations (irregular, rapid pulsation of the heart) and photophobia (abnormal fear of light). In few cases there are reports of blurred vision and in very rare cases temporary blindness is found. Cautions should be taken by the patients who also consume Protease inhibitors for the treatment of HIV as this increases the severity of side effects. Thus patients taking protease inhibitors are recommended to limit their dosage of sildenafil no more than 25mg pill every 48 hours.

WASHINGTON – The United States is retooling its global multibillion-dollar fight against HIV/AIDS to transform healthcare in some of the world’s poorest countries, the U.S. AIDS chief said on Tuesday.

Eric Goosby, who President Barack Obama named last year to take over the Bush administration’s signature foreign aid initiative, said U.S. AIDS relief efforts must change to face a broader health crisis stretching decades into the future.

“We’ve created a very good start at what was an emergency response. We now need to move that emergency response into a sustained response,” Goosby said in an interview.

“It’s a harder lift, it’s not as flashy, it’s not as rapid in our ability to deploy and put in place. But it is more durable.”

Former President George W. Bush launched the President’s Emergency Plan for AIDS Relief (PEPFAR) in 2003, pledging an initial $15 billion to fight AIDS around the world.

In 2008, the Democratic-controlled Congress authorized an additional $48 billion to fight AIDS, tuberculosis and malaria, and PEPFAR now operates in some 87 countries around the world, most of them in Africa but also including China and Russia.

Goosby, who has launched a new five-year strategy for PEPFAR, said it was time to address underlying healthcare problems in AIDS-hit countries — a huge expansion of program goals — even though the immediate crisis was far from over.

“We are still responding to an emergency in no uncertain terms. It is still killing millions of people,” Goosby said.

The AIDS virus infects 33 million people globally and about a million in the United States, but more people are living longer thanks to HIV drugs — many of them supplied through PEPFAR programs, according to a recent U.N. report.

Still, more than half the people who need life-saving drugs are not getting them, the World Health Organization and Joint U.N. Program on HIV/AIDS say.

BOLSTERING GOVERNMENT RESPONSE

Despite treatment successes, Goosby said in many target countries medical systems cannot cope with the long-term burden of AIDS and other diseases, requiring new strategies to bolster healthcare programs now often run by nongovernmental organizations (NGOs).

“They are there, they are connected, but they are as ephemeral as our funding line from year to year,” Goosby said of some of the existing programs.

The next step, Goosby said, will be to emphasize national health ministries and provincial health departments, using U.S. funds to equip and train local health workers to take up more of the healthcare burden.

Services such as anti-retroviral treatment, which often are administered by NGO-run centers or provincial hospitals, must be spread throughout national medical systems stretching down to village-level clinics, he said.

“There is now a very small amount of money going from the U.S. government to ministries of health, and that will undoubtedly increase once that transparency and accountability is in place and ensured,” he said.

Goosby said this would mean PEPFAR would act more as a technical advisor rather than a purveyor of drugs — although there are plans to get anti-retroviral drugs to 1.6 million more people over the next five years on top of the 2.4 million already receiving treatment thanks to the program.

Some critics have voiced fears that the changes will undercut one of the most successful public health initiatives ever launched, and one to which the United States has already committed more than $25 billion.

Altogether, PEPFAR is credited with helping to cut AIDS deaths by 10 percent in targeted African countries and saving more than a million lives, largely through supplying the anti-retroviral (ARV) drugs that can slow but not cure the disease.

Goosby said that overall the Obama administration’s commitment to global health projects was strong, although he conceded that tight economic times meant “we’ll be arguing to address the unmet need every year in our budget discussions.”

The fiscal year 2010 budget for PEPFAR includes $5.5 billion going directly to target countries for AIDS relief, up $61 million from 2009, and $1.05 billion for the Global Fund to Fight AIDS, Tuberculosis and Malaria, another major AIDS funding agency, up $50 million from the year before.

Those men suffering from erectile dysfunction (impotence) find the ultimate solace in Viagra (Sildenafil Citrate). Viagra is called the miracle drug for ED. It has been the God’s gift to those who have lost the power of normal sex and cannot experience a perfect erection for love making. But there have been lots of warnings with the use of Viagra. The thorough study of your medical history, diagnosis to find out the cause of impotence, and determination of the underlying causes of ED will help doctors to prescribe you the right and safe dose of Viagra.

While prescribing Viagra to you the doctor would tell you each and every small detail that you should keep in mind while you take Viagra. Since body metabolism of every one differs, the reaction to the medicine also varies from one person to another. Your system’s reaction to Sildenafil Citrate, in addition to possible interactions with other drugs you might be taking, determines the type and severity of the side effects you get from Viagra.

It is not necessary that if you take Viagra you will suffer from the side effects. There have been many instances where people experienced no side effects at all. The general side effects of Viagra found in the clinical trial are not to be worried about. These general and most common side effects include: headache, flushing, indigestion, congestion, and mild nervousness, as reported by greater percentage of patients. These side effects are nothing serious and one can bear them. The side effects slowly fade away. These side effects are not potential to cause any harm to your body.

Viagra may not be safe for everyone, so don’t take it unless you have talked to a doctor first, either physically or remotely through certified online pharmacies. Your prescription contains usage and safety instructions, so make sure you read and follow it carefully. In case you experience any unusual, long lasting, or very severe side effects you should immediately see your doctor or pharmacist.